Nicholas Hathaway, MD, PhD

Assistant Professor

Publications

  1. Ruybal-Pesántez S, Amaya-Romero J, Bérubé S, Brazeau NF, Diop MF, Hathaway N, Hendry JA, McCann K, Murie K, Murphy M, Niaré K, Phelan J, Schaffner SF, Simkin A, Taylor AR, Greenhouse B, Wesolowski A, Verity R. Toward an Open Analysis Ecosystem for Plasmodium Genomic Epidemiology. The American journal of tropical medicine and hygiene 2026. PMID: 42335881


  2. Kizza J, Katairo T, Kakuru A, Nsengimaana B, Esilu T, Wiringilimaana I, Semakuba FD, Gerlovina I, Hathaway N, Briggs J, Tukwasibwe S, Kiwuwa SM, Kamya MR, Nankabirwa JI, Dorsey G, Rosenthal PJ. Recurrent Plasmodium falciparum parasitemia and drug resistance mutations during intermittent preventive treatment of malaria in pregnancy in Uganda. The Journal of infectious diseases 2026. PMID: 41679334


  3. Katairo T, Asua V, Semakuba FD, Nsengimaana B, Kiyaga S, Hathaway N, Murie K, Tukwasibwe S, Wiringilimaana I, Nakasaanyaa J, Mwubaha C, Achom KB, Esilu TE, Ayitewalah A, Mbabazi M, Kabbale KD, Mulondo J, Watyekele E, Aranda-Diaz A, Maiteki CS, Opigo J, Dorsey G, Nsobya SL, Kamya MR, Agaba BB, Ssewanyana I, Greenhouse B, Rosenthal PJ, Briggs J, Conrad MD. Sustained high prevalence of multiple antimalarial drug resistance markers in Uganda in 2023-2024. Antimicrobial agents and chemotherapy 2026. PMID: 42294652


  4. Hathaway NJ, Murie K, Murphy M, Simkin A, Amaya-Romero J, Hubbard A, Briggs J, Aranda-Díaz A, Early AM, Wesolowski A, Neafsey DE, Bailey JA, Greenhouse B. The Portable Microhaplotype Object and Tools. bioRxiv : the preprint server for biology 2025. PMID: 41427304


  5. Zhang Y, Klein K, Ratcliff A, Galappaththi SL, Hathaway N, Twells N, Patel M, Temesy S, Bailey JA, Mahal LK, Creuzenet C, Arts EJ. Correction: Transmitted/founder (T/F) HIV-1 derived from sexual contact exhibits greater transmission fitness in human cervical tissue than T/F HIV-1 from blood-to-blood contact: Unique glycan profiles on T/F envelopes associated with transmission phenoty Volume 21 of Issue 11. PLoS pathogens 2025. PMID: 41252419


  6. López-Gutiérrez B, Hathaway N, Alonso-Palomares L, Nyasembe VO, Kato M, Hamerly T, Parr JB, Juliano JJ, Harbers M, Dinglasan RR. Evaluation of Plasmodium falciparum PSSP17 essentiality in human-to-mosquito transmission and its prospective candidacy as a biomarker. Volume 28 of Issue 12. iScience 2025. PMID: 41321633


  7. Kizza J, Katairo T, Kakuru A, Nsengimaana B, Esilu T, Wiringilimaana I, Semakuba FD, Gerlovina I, Hathaway N, Briggs J, Tukwasibwe S, Kiwuwa SM, Kamya MR, Nankabirwa JI, Dorsey G, Rosenthal PJ. Recurrent Plasmodium falciparum parasitemia and drug resistance mutations during intermittent preventive treatment of malaria in pregnancy in Uganda. medRxiv : the preprint server for health sciences 2025. PMID: 41282777


  8. Watson OJ, Tran TN, Zupko RJ, Symons T, Thomson R, Visser T, Rumisha S, Dzianach PA, Hathaway N, Kim I, Juliano JJ, Bailey JA, Slater H, Okell L, Gething P, Ghani A, Boni MF, Parr JB, Cunningham J. Global risk of selection and spread of Plasmodium falciparum histidine-rich protein 2 and 3 gene deletions. Volume 31 of Issue 10. Nature medicine 2025. PMID: 41053448


  9. Zhang Y, Klein K, Ratcliff A, Galappaththi SL, Hathaway N, Twells N, Patel M, Temesy S, Bailey JA, Mahal LK, Creuzenet C, Arts EJ. Transmitted/founder (T/F) HIV-1 derived from sexual contact exhibits greater transmission fitness in human cervical tissue than T/F HIV-1 from blood-to-blood contact: Unique glycan profiles on T/F envelopes associated with transmission phenotypes. Volume 21 of Issue 5. PLoS pathogens 2025. PMID: 40408432


  10. Ruybal-Pesántez S, Amaya-Romero J, Bérubé S, Brazeau NF, Diop MF, Hathaway N, Hendry J, McCann K, Murie K, Murphy M, Niaré K, Phelan J, Schaffner SF, Simkin A, Taylor AR, Greenhouse B, Wesolowski A, Verity R. Towards an open analysis ecosystem for Plasmodium genomic epidemiology. medRxiv : the preprint server for health sciences 2025. PMID: 40236429


  11. Aranda-Díaz A, Neubauer Vickers E, Murie K, Palmer B, Hathaway N, Gerlovina I, Boene S, García-Ulloa M, Cisteró P, Katairo T, Semakuba FD, Nsengimaana B, Gwarinda H, García-Fernández C, Louie W, Esayas E, Da Silva C, Datta D, Kiyaga S, Wiringilimaana I, Feleke SM, Bennett A, Smith JL, Gadisa E, Parr JB, Conrad MD, Raman J, Tukwasibwe S, Ssewanyana I, Rovira-Vallbona E, Tato CM, Briggs J, Mayor A, Greenhouse B. Sensitive and modular amplicon sequencing of Plasmodium falciparum diversity and resistance for research and public health. Scientific Reports 2025. PMID: 40155691


  12. Aranda-Díaz A, Vickers EN, Murie K, Palmer B, Hathaway N, Gerlovina I, Boene S, Garcia-Ulloa M, Cisteró P, Katairo T, Semakuba FD, Nsengimaana B, Gwarinda H, García-Fernández C, Da Silva C, Datta D, Kiyaga S, Wiringilimaana I, Fekele SM, Parr JB, Conrad M, Raman J, Tukwasibwe S, Ssewanyana I, Rovira-Vallbona E, Tato CM, Briggs J, Mayor A, Greenhouse B. Sensitive and modular amplicon sequencing of Plasmodium falciparum diversity and resistance for research and public health. bioRxiv : the preprint server for biology 2024. PMID: 39229023


  13. Hathaway NJ, Kim IE, WernsmanYoung N, Hui ST, Crudale R, Liang EY, Nixon CP, Giesbrecht D, Juliano JJ, Parr JB, Bailey JA. Interchromosomal segmental duplication drives translocation and loss of P. falciparum histidine-rich protein 3. Volume 13. eLife 2024. PMID: 39373634


  14. Chen YA, Vickers EN, Aranda-Diaz A, Murphy M, Gerlovina I, Rerolle F, Dantzer E, Hongvanthong B, Chang HH, Lover AA, Hathaway NJ, Bennett A, Greenhouse B. Genomic epidemiology demonstrates spatially clustered, local transmission of Plasmodium falciparum in forest-going populations in southern Lao PDR. PLoS pathogens 2024. PMID: 39312594


  15. Watson OJ, Tran TN, Zupko RJ, Symons T, Thomson R, Visser T, Rumisha S, Dzianach PA, Hathaway N, Kim I, Juliano JJ, Bailey JA, Slater H, Okell L, Gething P, Ghani A, Boni MF, Parr JB, Cunningham J. Global risk of selection and spread of Plasmodium falciparum histidine-rich protein 2 and 3 gene deletions. medRxiv : the preprint server for health sciences 2024. PMID: 37905102


  16. Cooper KM, Colletta A, Hathaway NJ, Liu D, Gonzalez D, Talat A, Barry C, Krishnarao A, Mehta S, Movahedi B, Martins PN, Devuni D. Delayed referral for liver transplant evaluation worsens outcomes in chronic liver disease patients requiring inpatient transplant evaluation. Volume 13 of Issue 4. World journal of transplantation 2023. PMID: 37388395


  17. da Silva C, Boene S, Datta D, Rovira-Vallbona E, Aranda-Díaz A, Cisteró P, Hathaway N, Tessema S, Chidimatembue A, Matambisso G, Nhama A, Macete E, Pujol A, Nhamussua L, Galatas B, Guinovart C, Enosse S, De Carvalho E, Rogier E, Plucinski MM, Colborn J, Zulliger R, Saifodine A, Alonso PL, Candrinho B, Greenhouse B, Aide P, Saute F, Mayor A. Targeted and whole-genome sequencing reveal a north-south divide in P. falciparum drug resistance markers and genetic structure in Mozambique. Communications biology 2023. PMID: 37291425


  18. Wamae K, Kimenyi KM, Osoti V, de Laurent ZR, Ndwiga L, Kharabora O, Hathaway NJ, Bailey JA, Juliano JJ, Bejon P, Ochola-Oyier LI. Amplicon Sequencing as a Potential Surveillance Tool for Complexity of Infection and Drug Resistance Markers in Plasmodium falciparum Asymptomatic Infections. Volume 226 of Issue 5. The Journal of infectious diseases 2022. PMID: 35429395


  19. Noviyanti R, Carey-Ewend K, Trianty L, Parobek C, Puspitasari AM, Balasubramanian S, Park Z, Hathaway N, Utami RAS, Soebianto S, Jeny J, Yudhaputri F, Perkasa A, Coutrier FN, Tirta YK, Ekawati L, Tjahyono B, Sutanto I, Nelwan EJ, Sudoyo H, Baird JK, Lin JT. Hypnozoite depletion in successive Plasmodium vivax relapses. Volume 16 of Issue 7. PLoS neglected tropical diseases 2022. PMID: 35867730


  20. Balasubramanian S, Curtis-Robles R, Chirra B, Auckland LD, Mai A, Bocanegra-Garcia V, Clark P, Clark W, Cottingham M, Fleurie G, Johnson CD, Metz RP, Wang S, Hathaway NJ, Bailey JA, Hamer GL, Hamer SA. Characterization of triatomine bloodmeal sources using direct Sanger sequencing and amplicon deep sequencing methods. Volume 12 of Issue 1. Scientific Reports 2022. PMID: 35715521


  21. Tessema SK, Hathaway NJ, Teyssier NB, Murphy M, Chen A, Aydemir O, Duarte EM, Simone W, Colborn J, Saute F, Crawford E, Aide P, Bailey JA, Greenhouse B. Sensitive, highly multiplexed sequencing of microhaplotypes from the Plasmodium falciparum heterozygome. The Journal of infectious diseases 2020. PMID: 32840625


  22. Feleke SM, Reichert EN, Mohammed H, Brhane BG, Mekete K, Mamo H, Petros B, Solomon H, Abate E, Hennelly C, Denton M, Keeler C, Hathaway NJ, Juliano JJ, Bailey JA, Rogier E, Cunningham J, Aydemir O, Parr JB. Plasmodium falciparum is evolving to escape malaria rapid diagnostic tests in Ethiopia. Volume 6 of Issue 10. Nature microbiology 2021. PMID: 34580442


  23. Cunningham CH, Hennelly CM, Lin JT, Ubalee R, Boyce RM, Mulogo EM, Hathaway N, Thwai KL, Phanzu F, Kalonji A, Mwandagalirwa K, Tshefu A, Juliano JJ, Parr JB. A novel CRISPR-based malaria diagnostic capable of Plasmodium detection, species differentiation, and drug-resistance genotyping. Volume 68. EBioMedicine 2021. PMID: 34139428


  24. Klein K, Nankya I, Nickel G, Ratcliff AN, Meadows AAJ, Hathaway N, Bailey JA, Stieh DJ, Cheeseman HM, Carias AM, Lobritz MA, Mann JFS, Gao Y, Hope TJ, Shattock RJ, Arts EJ. Deep Gene Sequence Cluster Analyses of Multi-Virus-Infected Mucosal Tissue Reveal Enhanced Transmission of Acute HIV-1. Volume 95 of Issue 3. Journal of virology 2021. PMID: 33177204


  25. Torrevillas BK, Garrison SM, McKeeken AJ, Patel D, Van Leuven JT, Dizon NI, Rivas KI, Hathaway NJ, Bailey JA, Waitumbi JN, Kifude CM, Oyieko J, Stewart VA, Luckhart S. Plasmodium falciparum DHFR and DHPS Mutations Are Associated With HIV-1 Co-Infection and a Novel DHPS Mutation I504T Is Identified in Western Kenya. Volume 10. Frontiers in cellular and infection microbiology 2020. PMID: 33324580


  26. Briggs J, Teyssier N, Nankabirwa JI, Rek J, Jagannathan P, Arinaitwe E, Bousema T, Drakeley C, Murray M, Crawford E, Hathaway N, Staedke SG, Smith D, Rosenthal PJ, Kamya M, Dorsey G, Rodriguez-Barraquer I, Greenhouse B. Sex-based differences in clearance of chronic Plasmodium falciparum infection. eLife 2020. PMID: 33107430


  27. Verity R, Aydemir O, Brazeau NF, Watson OJ, Hathaway NJ, Mwandagalirwa MK, Marsh PW, Thwai K, Fulton T, Denton M, Morgan AP, Parr JB, Tumwebaze PK, Conrad M, Rosenthal PJ, Ishengoma DS, Ngondi J, Gutman J, Mulenga M, Norris DE, Moss WJ, Mensah BA, Myers-Hansen JL, Ghansah A, Tshefu AK, Ghani AC, Meshnick SR, Bailey JA, Juliano JJ. The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC. Nature communications 2020. PMID: 32355199


  28. Mensah BA, Aydemir O, Myers-Hansen JL, Opoku M, Hathaway NJ, Marsh PW, Anto F, Bailey J, Abuaku B, Ghansah A. Antimalarial Drug Resistance Profiling of Plasmodium falciparum Infections in Ghana Using Molecular Inversion Probes and Next-Generation Sequencing. Volume 64 of Issue 4. Antimicrobial agents and chemotherapy 2020. PMID: 31932374


  29. Balasubramanian S, Rahman RS, Lon C, Parobek C, Ubalee R, Hathaway N, Kuntawunginn W, My M, Vy D, Saxe J, Lanteri C, Lin FC, Spring M, Meshnick SR, Juliano JJ, Saunders DL, Lin JT. Efficient Transmission of Mixed Plasmodium falciparum/vivax Infections From Humans to Mosquitoes. Volume 221 of Issue 3. The Journal of infectious diseases 2020. PMID: 31549156


  30. Brazeau NF, Assefa A, Mohammed H, Seme H, Tsadik AG, Parr JB, Keeler C, Hathaway NJ, Meshnick SR, Bailey JA, Kassa M, Juliano JJ, Woyessa A. Pooled Deep Sequencing of Drug Resistance Loci from Plasmodium falciparum Parasites across Ethiopia. Volume 101 of Issue 5. The American journal of tropical medicine and hygiene 2019. PMID: 31516103


  31. Hathaway NJ, Parobek CM, Juliano JJ, Bailey JA. SeekDeep: single-base resolution de novo clustering for amplicon deep sequencing. Volume 46 of Issue 4. Nucleic acids research 2018. PMID: 29202193


  32. Verity R, Hathaway NJ, Waltmann A, Doctor SM, Watson OJ, Patel JC, Mwandagalirwa K, Tshefu AK, Bailey JA, Ghani AC, Juliano JJ, Meshnick SR. Plasmodium falciparum genetic variation of var2csa in the Democratic Republic of the Congo. Volume 17 of Issue 1. Malaria journal 2018. PMID: 29361940


  33. Waltmann A, Patel JC, Thwai KL, Hathaway NJ, Parobek CM, Massougbodji A, Fievet N, Bailey JA, Deloron P, Juliano JJ, Ndam NT, Meshnick SR. Matched Placental and Circulating Plasmodium falciparum Parasites are Genetically Homologous at the var2csa ID1-DBL2X Locus by Deep Sequencing. Volume 98 of Issue 1. The American journal of tropical medicine and hygiene 2018. PMID: 29342401


  34. Miller RH, Hathaway NJ, Kharabora O, Mwandagalirwa K, Tshefu A, Meshnick SR, Taylor SM, Juliano JJ, Stewart VA, Bailey JA. A deep sequencing approach to estimate Plasmodium falciparum complexity of infection (COI) and explore apical membrane antigen 1 diversity. Volume 16 of Issue 1. Malaria journal 2017. PMID: 29246158


  35. Patel JC, Hathaway NJ, Parobek CM, Thwai KL, Madanitsa M, Khairallah C, Kalilani-Phiri L, Mwapasa V, Massougbodji A, Fievet N, Bailey JA, Ter Kuile FO, Deloron P, Engel SM, Taylor SM, Juliano JJ, Tuikue Ndam N, Meshnick SR. Increased risk of low birth weight in women with placental malaria associated with P. falciparum VAR2CSA clade. Volume 7 of Issue 1. Scientific Reports 2017. PMID: 28801627


  36. Ngondi JM, Ishengoma DS, Doctor SM, Thwai KL, Keeler C, Mkude S, Munishi OM, Willilo RA, Lalji S, Kaspar N, Kitojo C, Paxton LA, Hathaway NJ, Bailey JA, Juliano JJ, Meshnick SR, Gutman J. Surveillance for sulfadoxine-pyrimethamine resistant malaria parasites in the Lake and Southern Zones, Tanzania, using pooling and next-generation sequencing. Volume 16 of Issue 1. Malaria journal 2017. PMID: 28583119


  37. Brazeau NF, Hathaway N, Parobek CM, Lin JT, Bailey JA, Lon C, Saunders DL, Juliano JJ. Longitudinal Pooled Deep Sequencing of the Plasmodium vivax K12 Kelch Gene in Cambodia Reveals a Lack of Selection by Artemisinin. Volume 95 of Issue 6. The American journal of tropical medicine and hygiene 2016. PMID: 27799638


  38. Mideo N, Bailey JA, Hathaway NJ, Ngasala B, Saunders DL, Lon C, Kharabora O, Jamnik A, Balasubramanian S, Björkman A, Mårtensson A, Meshnick SR, Read AF, Juliano JJ. A deep sequencing tool for partitioning clearance rates following antimalarial treatment in polyclonal infections. Volume 2016 of Issue 1. Evolution, medicine, and public health 2016. PMID: 26817485


  39. Van Treuren W, Ponnusamy L, Brinkerhoff RJ, Gonzalez A, Parobek CM, Juliano JJ, Andreadis TG, Falco RC, Ziegler LB, Hathaway N, Keeler C, Emch M, Bailey JA, Roe RM, Apperson CS, Knight R, Meshnick SR. Variation in the Microbiota of Ixodes Ticks with Regard to Geography, Species, and Sex. Volume 81 of Issue 18. Applied and environmental microbiology 2015. PMID: 26150449


  40. Lin JT, Hathaway NJ, Saunders DL, Lon C, Balasubramanian S, Kharabora O, Gosi P, Sriwichai S, Kartchner L, Chuor CM, Satharath P, Lanteri C, Bailey JA, Juliano JJ. Using Amplicon Deep Sequencing to Detect Genetic Signatures of Plasmodium vivax Relapse. Volume 212 of Issue 6. The Journal of infectious diseases 2015. PMID: 25748326


  41. Parobek CM, Bailey JA, Hathaway NJ, Socheat D, Rogers WO, Juliano JJ. Differing patterns of selection and geospatial genetic diversity within two leading Plasmodium vivax candidate vaccine antigens. Volume 8 of Issue 4. PLoS neglected tropical diseases 2014. PMID: 24743266